We take a closer look at the current research being conducted following MEA Ramsay Research Fund investment.
1. Dr Keith Geraghty, University of Manchester
This study will centre around a national patient survey that will determine the factors affecting diagnosis and highlight any issues that may relate to delays in the diagnostic process.
It is very important that people presenting with symptoms are reviewed in a timely manner and are accurately diagnosed.
We hope that the analysed data when published will lead to improvements in the current process that will benefit future generations.
RRF Investment = £25,000
2. Dr Karl Morten et al. University of Oxford
Recently preliminary investigations at 3 independent laboratories highlighted that there may be an anomaly present in the blood plasma of people with ME/CFS that is adversely affecting mitochondrial performance in healthy cells.
Dr Morten and his team will attempt to determine if this anomaly can be isolated and identified. They will be working closely with Dr Pawel Zalewski from Nicolaus Copernicus University, in Poland and using samples from his own work on ME.
RRF Investment = c.£75,000
3. Dr Keith Geraghty, University of Manchester
Critical examination of the theoretical basis that underlies the use of cognitive behaviour therapy (CBT) and graded exercise therapy (GET) in ME/CFS.
This two year award has been given to Dr Keith Geraghty at the University of Manchester and will challenge and review the theoretical basis and clinical application of CBT and GET in the NHS.
This new grant will fund an incremental study, in two main phases. Phase 1 being a theoretical exploration of the CBT-model of ME/CFS and phase 2 being an empirical study of patients’ experiences of CBT and GET.
The aim of the study is to better understand why clinical trials are reporting seemingly different effects than are demonstrated in patient surveys and clinical outcomes.
RRF investment = £25,000
4. Dr Karl Morten et al., Universities of Oxford and Newcastle
Scientists from the Universities of Oxford and Newcastle are spending 12 months analysing nearly 300 blood samples from the UK ME/CFS Biobank to look for small molecular clues known as metabolites. These are left behind after chemical reactions have taken place at a cellular level.
It is hoped that this research will identify patterns of metabolites that could help to form either a diagnostic test for ME/CFS or help to sub-group people that come under the ME/CFS umbrella.
The UK research will also try to replicate the findings from an important 2016 metabolomic study by Dr Robert Naviaux, which suggested that ME/CFS could be caused by the body going into a state of semi-hibernation.
Dr Morten is working alongside Professor James McCullagh, Associate Professor in Mass Spectrometry at the University of Oxford, and Professor Julia Newton, Dean for Clinical Medicine at Newcastle University.
- August 2018 MEA Research Update: Metabolomics and ME/CFS – Dr Morten and the Oxford Research Centre.
Funding for this research came largely from the 2016 ME Association Christmas Appeal which raised £70,000. The remainder has come from the MEA Ramsay Research Fund.
RRF investment = £100,000
5. Professor Elisa Oltra et al., University of Valencia, Spain
Using blood samples from the cohort of people with severe ME/CFS that are stored at the ME/CFS Biobank, Professor Elisa Oltra and colleagues in Spain are aiming to build up a detailed picture of changes in what are called micro RNA profiles – along similar lines to what they have already discovered in people with fibromyalgia.
- Dr Charles Shepherd wrote a summary about this research study when the original grant investment was announced in December 2016.
The research is now nearing completion and some preliminary results were presented at an international research conference in May 2018.
RRF investment = £50,000
6. Dr Luis Nacul et al., LSHTM ME/CFS Biobank team and University College London
This research study will further examine both immune system dysfunction in ME/CFS and defects in the way that energy is being produced at a cellular level.
The B- and T-cell main study will examine samples from 100 patients (50 moderate: 50 severe) and 100 controls (50 healthy: 50 MS) using flow cytometry.
The immune system component will build on some existing research findings relating to T and B cell status in ME/CFS and will be based at the London School of Hygiene and Tropical Medicine (LSHTM).
The T cell work has been carried out at the LSHTM using samples from the UK ME/CFS Biobank. The results of this research are currently being prepared for publication. The LSHTM project team will be led by Dr Luis Nacul and Dr Jackie Cliff.
This new research will investigate how abnormalities in this part of the immune system are linked with evidence that is now emerging of a disturbance in the way that energy is being produced at a cellular level in ME/CFS.
The T and B cell research will be using blood samples from the ME/CFS Biobank – where we have biological samples and clinical data from 284 people with ME/CFS (including with severe ME/CFS), 60 people with multiple sclerosis and 135 healthy controls.
It will draw on the expertise not only of the CureME clinical research team but also of other experts in immunology at the LSHTM.
This research will also involve a small pilot collaboration with Dr Christopher Armstrong’s research team in Australia – who are looking at metabolic (chemical) changes in the blood that occur during energy production.
RRF investment = c.£50,000
The ME Association Ramsay Research Fund
We are a national charity working hard to improve the lives of people devastated by an often-misunderstood neurological disease.
We believe biomedical research offers the best hope to people affected by M.E. If you would like to support our investment then please donate to the Ramsay Research Fund.
Just click the image opposite to visit our JustGiving page for single donations, to establish a regular payment or to begin fundraising.
ME Association Registered Charity Number 801279
Other pages in this section:
- UK ME/CFS Biobank
- Current Studies
- Post-Mortem Tissue Bank and Tissue Donation
- Pathology of CFS
- ME/CFS Disease Register
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