Research: Chinese study into role of CD25 + Regulative T cell in development of CFS, February 2012

From Labeled Immunoassays and Clinical Medicine, February 2012

Expression of Lymphocyte Subsets and CD25+ Regulative T Cells in Peripheral Blood of Patients with Chronic Fatigue Syndrome

LIU Ding-hua, LIU Zhan-dong, LI Yong-zhe, ZHANG Hai-ying, HU Chao-jun, ZHANG Yong-bo, WHANG De-xin
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730, China.

Abstract

To investigate the expression of lymphocyte subsets and CD25+ regulative T cells in peripheral blood of patients with chronic fatigue syndrome(CFS).

Eighty-four CFS patients and fifty healthy volunteers were enrolled in this study. Their peripheral blood was sampled, and the lymphocyte subsets and CD25+ regulative T cells were measured by flow cytometry.

The results showed that the NK cells, CD4+T cells and CD25+ regulative T cells in CFS patients were higher and B cells were lower than that of healthy controls(P0.05), while there was no significant difference between CFS patients and healthy controls with respect to the percentage of T cells and CD8+T cells and CD4+/CD8+ ratio(P0.05).

The results indicated that CD25+ regulative T cell might play an important role in CFS-related immunological abnormality, and be involved in the progress of CFS.